PBBs: potential effects in children.

نویسنده

  • T A Tsongas
چکیده

1. Ashby J. a2p-Globulin nephropathy in white ravens [letter]. Environ Health Perspect 104 (12):1264 (1996). 2. Baserga R The cell cycle: myths and realities. Cancer Res 50:6769-6771 (1990). 3. Barrett JC, Huff JE. Cellular and molecular mechanisms of chemically induced renal carcinogenesis. In: Nephrotoxicity. Mechanisms, early diagnosis, & therapeutic management (Bach PH, Gregg NJ, Wiks MF, Delacruz L eds). New York:Marcel Dekker, 1991;287-306. [Reprinted revised and updated in Renal Failure 13:211-225 (1991).] 4. Melnick R. An alternative hypothesis on the role of chemically induced protein droplet (a2p -globulin) nephropathy in renal carcinogenesis. Regul Toxicol Pharmacol 16:111-125 (1992). 5. Melnick R Critique does not validate assumptions in the model on a2p -globulin and renal carcinogenesis. Regul Toxicol Pharmacol 16:111-125 (1992). 6. Huff JE. Mechanisms, chemical carcinogenesis, and risk assessment: cell proliferation and cancer. Am J Ind Med 27:293-300 (1995). 7. Huff JE. Chemical toxicity & chemical carcinogenesis. Is there a causal connection? A comparative morphological evaluation of 1500 experiments. In: Mechanisms of carcinogenesis in risk identification (Vainio H, Magee P, McGregor D, McMichael A, eds), IARC scientific publication no. 116. Lyon:International Agency for Research on Cancer, 1992;437-475. 8. Huff JE. Absence of morphologic correlation between chemical toxicity and chemical carcinogenesis. Environ Health Perspect 101 (suppl 5):45-54 (1993). 9. Siemiatycki J, Dewar R, Genn M, Richardson L, Wacholder S. Associations between several sites of cancer and twelve petroleum-based liquids. Results from a case-referent study in Montreal. Scand J Work Environ Health 13:493-504 (1987). 10. Partanen T, Heikkila P, Hernberg S, Kauppinen T, Moneta G, Ojajarvi A. Renal cell cancer and occupational exposure to chemical agents. Scand J Work Environ Health 17:231-239 (1991). 11. Henschler D, Vamvakas S, Lammert M, Dekant W, Kraus B, Thomas B, Ulm K. Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroethene. Arch Toxicol 69:291-299 (1995). 12. Henschler D, Vamvakas S, Lammert M, Dekant W, Kraus B, Thomas B, Ulm K. Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroethylene. Arch Toxicol 70:131-133 (1995). 13. Sigler RE, Gough AW, de la Iglesia FA. Pancreatic acinar cell neoplasia in male Wistar rats following 2 years of gabapentin exposure. Toxicology 98:83-82 (1995). 14. Fowler ML, Sigler RE, de la Iglesia FA, Reddy JK, Lalwani ND. Absence of Ki-ras mutations in exocrine pancreatic tumors from male rats chronically exposed to gabapentin. Mutat Res 327:151-160 (1995). 15. Dominick MA, Robertson DG, Bleavins MR, Sigler RE, Bobrowski WF, Gough AW. a2pGlobulin nephropathy without nephrocarcinogenesis in male Wistar rats administered 1[aminomethyl]cyclohexaneacetic acid. Toxicol Appl Pharmacol 111:375-387 (1991). 16. Dichter MA, Brodie MJ. New antilepileptic drugs. N EnglJ Med 334:1583-1590 (1996). 17. Dietrich DR, Swenberg JA. Lindane induces nephropathy and renal accumulation of a2pglobulin in male but not in female Fischer rats or in male NBR rats. Toxicol Lett 53:179-181 (1990). 18. IARC. IARC monographs on the evaluation of carcinogenic risk of chemicals to humans, vol 5. Some organochlorine pesticides. Lyon: International Agency for Research on Cancer, 1974;47-74. 19. IARC. IARC monographs on the evaluation of carcinogenic risk of chemicals to humans, vol 20. Some halogenated hydrocarbons. Lyon:International Agency for Research on Cancer, 1979;159-239. 20. IARC. IARC monographs on the evaluation of carcinogenic risk of chemicals to humans, suppl 7. Overall evaluations of carcinogenicity: an updating of IARC monographs volumes 1-42. Lyon:International Agency for Research on Cancer, 1987. 21. Gaworski CL, Haun CC, MacEwen JD, Vernot CH, Bruner RH, Amster RL, Cowan MJ Jr. A 90-day vapor inhalation toxicity study of decalin. Fundam Appl Toxicol 5:785-793 (1985). 22. Borghoff SJ. a2p-Globulin-mediated male rat nephropathy and kidney cancer: relevance to human risk assessment. CIIT Act 13:1-8 (1993). 23. NTP. Toxicology and carcinogenesis studies of dimethyl methylphosphonate (CAS No. 756-796) in F344/N rats and B6C3F1 mice (gavage studies). Technical report no 323. Research Triangle Park, NC:National Toxicology Program, 1986. 24. Dunnick JK, Eustis SL, Haseman JK. Development of kidney tumors in the male F344/N rat after treatment with dimethyl methylphosphonate. Fundam Appl Toxicol 11:91-98 (1988). 25. NTP. Toxicology and carcinogenesis studies of t-butyl alcohol (CAS No. 75-65-0) in F344/N rats and B6C3F1 mice (drinking water studies). Technical report no 436. Research Triangle Park, NC:National Toxicology Program, 1995. 26. Cirvello JD, Radovsky A, Heath JE, Farnell DR, Lindamood C. Toxicity and carcinogenicity of t-butyl alcohol in rats and mice following chronic exposure in drinking water. Toxicol Ind Health 11:151-165 (1995). 27. Bouthillier L, Greselin E, Brodeur J, Viau C, Charbonneau M. Male rat specific nephrotoxicity resulting from subchronic administration of hexachlorobenzene. Toxicol Appl Pharmacol 110:315-326 (1991). 28. Erturk E, Lambrecht RW, Peters HA, Cripps DJ, Gocmen A, Morris CR, Bryan GT. Oncogenicity of hexachlorobenzene. In: Hexachlorobenzene: proceedings of an international symposium (Morris CR, Cabral JRP, eds), IARC scientific publication no. 77. Lyon:International Agency for Research on Cancer, 1986;417-423. 29. Cabral JRP, Shubik P. Carcinogenic activity of hexachlorobenzene in mice and hamsters. In: Hexachlorobenzene: proceedings of an international symposium (Morris CR, Cabral JRP, eds). IARC scientific publication no. 77. Lyon:International Agency for Research on Cancer, 1986;411-416. 30. Fowler BA, DuVal G. Effects of lead on the kidney: roles of high-affinity lead-binding proteins. Environ Health Perspect 91:77-80 (1991). 31. Kahng MW, Conner EA, Fowler BA. Leadbinding proteins (PbBP) in human tissues [abstract]. Toxicologist 12:214 (1992). 32. Huff J, Cirvello J, Haseman J, Bucher J. Chemicals associated with site-specific neoplasia in 1394 long-term carcinogenesis experiments in laboratory rodents. Environ Health Perspect 93:247-270 (1991). 33. Short BG. Cell proliferation and renal carcinogenesis. Environ Health Perspect 101(suppl 5):115-120 (1993). 34. Farber E. Cell proliferation as a major risk factor for cancer: a concept of doubtful validity. Cancer Res 55:3759-3762 (1996). 35. Foulds L. Neoplastic development. New York:Academic Press, 1969.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Assessment of the hazards of polybrominated biphenyls.

During their peak use period, PBBs represented under 1% of the total sales of fire retardant chemicals, and very probably would have escaped intensive study if they had not been mixed accidentally with animal feed preparations. Instead, international attention was drawn to PBBs by the state-supervised killing of over 35,000 cattle which had been contaminated with PBBs. Interestingly, low doses ...

متن کامل

Effects of polybrominated biphenyls on kidney function and activity of renal microsomal enzymes.

Polybrominated biphenyls (PBBs) cause hepatic microsomal enzyme stimulation and histopathological alterations in several organs, including kidney. Concern about effects of PBBs on the health of newborns has increased after the discovery of PBBs in milk of nursing mothers. Therefore, it was of interest to investigate the effects of PBBs on kidney function and the activity of renal microsomal enz...

متن کامل

Induction of drug metabolizing enzymes in polybrominated biphenyl-fed lactating rats and their pups.

Polybrominated biphenyls (PBBs) cause a mixed-type (phenobarbital- plus 3-methylcholanthrene-like) induction of liver microsomal drug metabolizing enzymes in rats. However, 2,2',4,4',5,5'-hexabromobiphenyl and 2,2',3,4,4',5,5'-heptabromobiphenyl, which together comprise less than 80% of PBBs (FireMaster), were shown to be strictly phenobarbital-type inducers. Other components (unidentified) mus...

متن کامل

[11C]vinpocetine: a prospective peripheral benzodiazepine receptor ligand for primate PET studies.

Vinpocetine, a synthetic derivative of the Vinca minor alkaloid vincamine, is a widely used drug in neurological practice. We tested the hypothesis that vinpocetine binds to peripheral benzodiazepine binding sites (PBBS) and is therefore a potential ligand of PBBS. Positron emission tomography (PET) measurements in two cynomolgous monkeys showed that pretreatment with vinpocetine markedly reduc...

متن کامل

Effects of processing and cooking on PBB residues.

To study the effect of processing on polybrominated biphenyl (PBB) levels, milk from four dairy herds containing less than 0.3 ppm (fat basis) of physiologically incorporated PBBs was presented individually into cream, skim milk, butter, and stirred curd cheese. Pasteurized and freeze-dried whole milk, skim milk, and cream, spray-dried whole milk and skim milk, and condensed whole milk were als...

متن کامل

Pediatric health aspects of PBBs.

Many Michigan farm children are viewed as having suffered a deterioration in health coincident with contamination of dairy cattle by PBBs. Among Wisconsin dairy farm children such a deterioration was a rare event. There is a suggestion that Michigan farm children who had multiple symptoms during the 1973-76 period are getting better. A discrete syndrome of ill health has not been identified amo...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Environmental Health Perspectives

دوره 104  شماره 

صفحات  -

تاریخ انتشار 1996